The Glade 4.0
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What Doesn't Kill You Makes You Stronger
https://gladerebooted.net/viewtopic.php?f=2&t=5216
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Author:  FarSky [ Tue Jan 11, 2011 5:18 pm ]
Post subject:  What Doesn't Kill You Makes You Stronger

You know...with science!

http://io9.com/5730895/

Quote:
Swine flu gives its survivors supercharged immunity, could create universal flu vaccine

The swine flu pandemic of 2009 was one of the worst flu scares in recent memory, even if its actual effects ended up being relatively moderate. Now something unambiguously good could come of all this: a universal flu vaccine.

As many as sixty million people were infected with the H1N1 virus, although only about 18,000 people are known to have died from the disease. What researchers are now discovering is what swine flu leaves behind: a superpowered immune system with antibodies that can kill off any new flu virus, not just a return of H1N1.

Recent research on nine swine flu survivors revealed that the infection had caused all their immune systems to go into overdrive, creating a huge range of flu antibodies that aren't needed to fight off swine flu but would be very useful if any number of other flu strains tried to invade the subjects' bodies. More common flu strains like the seasonal flu or the very mild flu virus used to create the flu vaccine don't activate this many antibodies, suggesting there's something unusual about H1N1 that triggers this powerful immune response.

The power of the H1N1 immune response is extraordinary. According to the researchers, five of the types of antibodies isolated in their research would be enough to fight off all seasonal flu variations, the Spanish flu virus that killed as many as 50 million people in the pandemic of 1918, and a potentially deadly bird flu strain known as H5N1.

The researchers say the uniqueness of the swine flu is what triggered this response. The immune system didn't immediately know what to do with the virus, so it started creating lots of different antibodies based on its memory of other flu viruses it had previously encountered. By the time the immune system found the right antibodies to fight off the swine flu, enough had been created to ward off all other influenza variants as well. We don't know yet whether the H1N1 vaccine also transferred these super immunity properties, although that's next on the researchers' to-do list.

Oxford University virus expert Dr. Sarah Gilbert, this could well lead us to a universal flu vaccine, and in the relatively near future, too:

"Many scientists are working to develop a vaccine that would protect against the many strains of flu virus. This work gives us more confidence that it will be possible to generate a universal flu vaccine. It will take at least five years before anything like this could be widely available."

Five years is a long time to wait, but considering that as many as 500,000 people die every year from various flu strains, it seems like a universal vaccine is very much worth waiting for.

Author:  Kaffis Mark V [ Tue Jan 11, 2011 6:24 pm ]
Post subject: 

That's funny. I don't feel super-immune. Do you, 'Skee? *glares at psifonian*

Author:  Corolinth [ Tue Jan 11, 2011 7:02 pm ]
Post subject: 

So basically, H1N1 gave us root access to the flu.

Author:  Hopwin [ Wed Jan 12, 2011 8:03 am ]
Post subject:  Re:

Corolinth wrote:
So basically, H1N1 gave us root access to the flu.

I'd add this to the quote thread but I don't think enough people would get it :(

Author:  Vindicarre [ Wed Jan 12, 2011 1:21 pm ]
Post subject: 

I think you'd be surprised.
That thread is about your favorite Glade quotes, not your favorite Glade quotes that everyone will like too, isn't it?

Author:  Hopwin [ Wed Jan 12, 2011 1:51 pm ]
Post subject:  Re:

Vindicarre wrote:
I think you'd be surprised.
That thread is about your favorite Glade quotes, not your favorite Glade quotes that everyone will like too, isn't it?

We'd have to ask LK, it was her idea IIRC.

Author:  Colphax [ Wed Jan 12, 2011 2:28 pm ]
Post subject: 

It was LK's and mine (mostly LK's, though). LK's original thread was limited to favotite quotes of 2009, then I suggested making a running quotes thread. But since her thread already had lots of quotes in it, my generalized Quote Bank thread died, and LK's original thread title dropped the "of 2009" part.

And considering the title of the stickied thread is "Your Fave Glade Quotes"...

Author:  Hopwin [ Wed Jan 12, 2011 3:21 pm ]
Post subject: 

Too late, this conversation has gotten too awkward for me to follow either course of action comfortably so default of not changing positions applies.

Author:  Kirra [ Wed Jan 12, 2011 10:52 pm ]
Post subject: 

What do you all do? Get the flu vaccine? Or say no way, it makes me sick..

Author:  darksiege [ Thu Jan 13, 2011 2:33 am ]
Post subject: 

Every time I get the damn vaccine I get sick so F that.

I have my friend Nighttime Tylenol that Mus introduced me to... when I get sick I vap-o-rub and Tylenol that bastard away.

Author:  Müs [ Thu Jan 13, 2011 7:11 am ]
Post subject:  Re:

Kirra wrote:
What do you all do? Get the flu vaccine? Or say no way, it makes me sick..


No freakin way. Strangely, my immune system is strong like bull.

Author:  Oonagh [ Thu Jan 13, 2011 9:17 am ]
Post subject:  Re: What Doesn't Kill You Makes You Stronger

I just let RNAi take care of it, hopefully it works.

Author:  Talya [ Thu Jan 13, 2011 9:40 am ]
Post subject:  Re:

Kirra wrote:
What do you all do? Get the flu vaccine? Or say no way, it makes me sick..


I suffer some major anxiety any time I get a needle, with no idea why. I put on a brave face, then look away and bite my lip, but have no obvious trouble at the time they stick the needle in me. Then I start seeing stars, like the blood is rushing away from my brain, and I frequently pass out within 5-10 minutes after getting any syringe stuck into me. (Funny, it takes that long.) Funny thing is, I get similar symptoms watching my kids get needles, which is terrible because I am trying to reassure them that its fine. I can't even watch someone get an injection on television.

So no, I do not get the flu shot.

Author:  Oonagh [ Thu Jan 13, 2011 9:55 am ]
Post subject:  Re: Re:

Talya wrote:
Kirra wrote:
What do you all do? Get the flu vaccine? Or say no way, it makes me sick..


I suffer some major anxiety any time I get a needle, with no idea why. I put on a brave face, then look away and bite my lip, but have no obvious trouble at the time they stick the needle in me. Then I start seeing stars, like the blood is rushing away from my brain, and I frequently pass out within 5-10 minutes after getting any syringe stuck into me. (Funny, it takes that long.) Funny thing is, I get similar symptoms watching my kids get needles, which is terrible because I am trying to reassure them that its fine. I can't even watch someone get an injection on television.

So no, I do not get the flu shot.



I think it is a redhead thing, because it happens to me too. I also have the nauseated stomach afterwards and feel like I am seeing stars.

Author:  TheRiov [ Thu Jan 13, 2011 10:24 am ]
Post subject: 

I'm a baby about needles too. I'll take punches in the arm all day. Needles make me squirm and barely hurt.

Author:  NephyrS [ Thu Jan 13, 2011 10:25 am ]
Post subject:  Re: What Doesn't Kill You Makes You Stronger

Oonagh wrote:
I just let RNAi take care of it, hopefully it works.


Eh? I wasn't aware of any significant RNA interference therapies that had made it to market. I'm confused, and I wish to know more!

Author:  LadyKate [ Thu Jan 13, 2011 11:45 am ]
Post subject: 

I have no problem getting shots, that doesn't bother me, its drawing blood that makes me pass out.
And yeah, the Quotes thread is for whatever YOU think is memorable and quote-worthy, not just me or Colphax.
What the heck is RNAi?
I've only gotten the flu-shot twice and I've only had the flu a couple of times in my life (unrelated to the shot.) I did not get the H1N1 vaccine as I was preggers at that time, but my son got the swine flu and he ran a high fever for several days but no other symptoms...didn't even affect his appetite or anything.

Author:  NephyrS [ Thu Jan 13, 2011 12:00 pm ]
Post subject: 

RNAi is short for RNA interference, which is the use of short RNA sequences (20-25 base pairs) as post-transcriptional silencing.

Basically, you have a short RNA sequence that binds to the 3'untranslated region of a messenger RNA transcript, and either induces degradation or prevents translation, depending on the specific interference mechanism at play.

RNA-based therapeutics are used in cancer treatments, cardiovascular therapies, and others- as are inhibitors of endogenous miRNA, which is the major player in humans RNAi response.

RNAi based therapeutics can be used to "kick start" the bodies RNAi system to create new miRNAs or siRNAs (small interfering RNAs) which target viral RNA and prevent its transcription, halting viral replication.

I just wasn't aware that there was really any native RNAi response to the virus without a therapeutic to kick start it- and the only therapeutics I know haven't made it into use in humans yet.

Author:  Arathain Kelvar [ Thu Jan 13, 2011 12:24 pm ]
Post subject: 

Great, so the gov pushed us all to get the vaccine, and those that didn't are better off. Except for the 18,000 that died, of course....

Author:  Vindicarre [ Thu Jan 13, 2011 12:38 pm ]
Post subject: 

That's 18,000 worldwide, right?

Author:  Lenas [ Thu Jan 13, 2011 1:59 pm ]
Post subject:  Re:

Vindicarre wrote:
That's 18,000 worldwide, right?
Yeah, and that was only "approximately 4% of the 250,000 to 500,000 annual influenza deaths."


Arathain Kelvar wrote:
Great, so the gov pushed us all to get the vaccine, and those that didn't are better off.
Of course they did. Why would the government not want its people to get protected? They couldn't have known that actually getting the virus would make you a super human.

Author:  Raltar [ Thu Jan 13, 2011 2:40 pm ]
Post subject: 

I've never gotten a flu shot. But I only get the flu maybe once every 7 or 8 years.

Author:  Kirra [ Thu Jan 13, 2011 4:07 pm ]
Post subject:  Re: Re:

Talya wrote:
Kirra wrote:
What do you all do? Get the flu vaccine? Or say no way, it makes me sick..


I suffer some major anxiety any time I get a needle, with no idea why. I put on a brave face, then look away and bite my lip, but have no obvious trouble at the time they stick the needle in me. Then I start seeing stars, like the blood is rushing away from my brain, and I frequently pass out within 5-10 minutes after getting any syringe stuck into me. (Funny, it takes that long.) Funny thing is, I get similar symptoms watching my kids get needles, which is terrible because I am trying to reassure them that its fine. I can't even watch someone get an injection on television.

So no, I do not get the flu shot.


Bet I could give you a shot and you wouldn't pass out..I have never had anyone do that and several have been deathly afraid of needles.

I'm good. :)

Author:  Midgen [ Thu Jan 13, 2011 11:26 pm ]
Post subject: 

I used to get them when the Military mandated them.

Now I just don't usually bother. There have been times when I did get them and still got sick, and many flu seasons have passed without getting sick when I had no flu shot.

If my workplace is giving free flu shots and I'm in the area, I'll get one if it's convenient.

Author:  Rodahn [ Thu Jan 20, 2011 6:19 pm ]
Post subject:  Re: What Doesn't Kill You Makes You Stronger

I generally only have minor illnesses thanks to a fairly strong immune system, but today I woke up and felt kinda bleh.

As the day wore on, it slowly got worse.

Now I feel like I've been shot at and missed, and **** on and hit.

FU sickness!

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