The purpose of this Mission Design Handbook is to provide trajectory designers and mission planners with graphical information about Earth to Mars ballistic trajectory opportunities for the years of 2026 through 2045. The plots, displayed on a departure date/arrival date mission space, show departure energy, right ascension and declination of the launch asymptote, and target planet hyperbolic arrival excess speed, V(sub infinity), for each launch opportunity. Provided in this study are two sets of contour plots for each launch opportunity. The first set of plots shows Earth to Mars ballistic trajectories without the addition of any deep space maneuvers. The second set of plots shows Earth to Mars transfer trajectories with the addition of deep space maneuvers, which further optimize the determined trajectories. The accompanying texts explains the trajectory characteristics, transfers using deep space maneuvers, mission assumptions and a summary of the minimum departure energy for each opportunity.