Manifest Destiny was always restricted to North (whoops, or South, now that I look it up) America.
http://en.wikipedia.org/wiki/Common_Sense_(pamphlet)
"[Being a part of Britain would drag America into unnecessary European wars, and keep it from the international commerce at which America excelled.]"
http://en.wikipedia.org/wiki/George_Was ... Free_Trade35 Against the insidious wiles of foreign influence (I conjure you to believe me, fellow-citizens,) the jealousy of a free people ought to be constantly awake; since history and experience prove, that foreign influence is one of the most baneful foes of Republican Government. But that jealousy, to be useful, must be impartial; else it becomes the instrument of the very influence to be avoided, instead of a defence against it. Excessive partiality for one foreign nation, and excessive dislike of another, cause those whom they actuate to see danger only on one side, and serve to veil and even second the arts of influence on the other. Real patriots, who may resist the intrigues of the favorite, are liable to become suspected and odious; while its tools and dupes usurp the applause and confidence of the people, to surrender their interests.
36 The great rule of conduct for us, in regard to foreign nations, is, in extending our commercial relations, to have with them as little political connexion as possible. So far as we have already formed engagements, let them be fulfilled with perfect good faith. Here let us stop.
37 Europe has a set of primary interests, which to us have none, or a very remote relation. Hence she must be engaged in frequent controversies, the causes of which are essentially foreign to our concerns. Hence, therefore, it must be unwise in us to implicate ourselves, by artificial ties, in the ordinary vicissitudes of her politics, or the ordinary combinations and collisions of her friendships or enmities.
Jefferson was well-known and remembered for "Peace, commerce and honest friendship with all nations; entangling alliances with none" in his inaugural address.
The Monroe Doctrine is considered the codification of Manifest Destiny -- and it specifically says that so long as Europe doesn't try to interfere on this side of the Atlantic, the US will butt the hell out and leave them alone to play nice or wage war amongst themselves as they wish. It's only further attempts to colonize in North or South America that would be considered acts of war.